RETN

Across TCGA cell cohorts, RETN RNA expression is significantly associated with the go_rna of many other GO terms, with 576 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RETN-associated GO terms across cancer lineages are Positive regulation of SREBP signaling pathway, Positive regulation of muscle contraction, and Regulation of protein localization to nucleus. Each is linked with RETN in more than 3 cancer types. Because this analysis shows association rather than direction, both RETN-to-partner and partner-to-RETN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of SREBP signaling pathway grouped by RETN-low versus RETN-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RETN→partner) and Y-score (partner→RETN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Positive regulation of SREBP signaling pathway →	+0.064	+0.034	.007	.004	2	4
CNS	Positive regulation of muscle contraction →	-0.099	-0.032	.001	.007	3	3
LARGE_INTESTINE	Regulation of protein localization to nucleus →	+0.043	+0.044	.005	.006	3	3
BLOOD_Leukemia	Regulation of SREBP signaling pathway →	+0.041	+1.870	.008	.003	3	3
BLOOD_Leukemia	Nerve development →	-0.039	-2.056	.003	.001	3	3
BLOOD_Leukemia	Gonad development →	+0.045	+1.815	.008	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 576 associations by consensus.

Positive regulation of SREBP signaling pathway by RETN expression — CNS

Explore this box plot interactively →