RETN

Across TCGA pan-cancer cohorts, RETN RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of RETN’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RETN RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RETN is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

KIRC, COAD, and LUAD are the cancer types where RETN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RETN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	IV	+1.172	<.001	12	view →
COAD	All	III,IV	+0.997	<.001	11	view →
LUAD	Male	II,III,IV	−3.734	<.001	9	view →
THCA	All	III,IV	+1.774	<.001	9	view →
LUSC	Male	III,IV	−5.055	<.001	8	view →
STAD	All	All	+0.474	.009	5	view →
HNSC	Female	All	+0.363	.004	4	view →
ESCA	All	II,III,IV	+1.004	.018	2	view →
CHOL	Male	All	+0.669	.008	2	view →
KIRP	All	All	+0.579	.004	2	view →
KICH	Female	II,III,IV	−0.624	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

RETN–KIRC

Open the KIRC breakdown →