RETN

Across TCGA pan-cancer cohorts, RETN RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated RETN data layer compared with 8 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher RETN RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RETN expression acts as an unfavorable survival marker, although some lineages such as SKCM and LAML show a favorable association.

SCLC, LUSC, and KIRP are the cancer types where RETN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Tertile	II,III,IV	0.224	0.600	<.001	69	view →
LUSC	OS	Quartile	All	0.287	0.499	<.001	62	view →
KIRP	DFS	Median	II,III,IV	0.477	1.000	.001	56	view →
KIRC	OS	Quartile	II,III,IV	0.695	0.891	<.001	55	view →
HNSC	OS	Tertile	All	0.675	0.793	.003	52	view →
SKCM	DFS	Median	II,III,IV	0.325	0.189	.001	46	view →
CESC	DFS	Median	All	0.658	0.814	<.001	34	view →
GBM	OS	Tertile	All	0.309	0.484	.002	30	view →
LAML	DFS	Median	All	0.730	0.424	<.001	28	view →
LGG	DFS	Quartile	All	0.281	0.497	<.001	21	view →
MESO	OS	Tertile	IV	0.327	0.853	.006	16	view →
CHOL	DFS	Tertile	All	0.837	0.149	.012	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

RETN–SCLC (OS)

Open the SCLC breakdown →