RET

Across TCGA patient cohorts, RET mutation is significantly associated with the total protein of many other genes, with 107 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RET-associated genes across cancer lineages are FoxM1, Cyclin-B1, and eEF2. Each is linked with RET in more than 3 cancer types. Because this analysis shows association rather than direction, both RET-to-partner and partner-to-RET results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by RET-low versus RET-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RET→partner) and Y-score (partner→RET) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	FoxM1 →	+0.491	+3.169	<.001	.019	3	4
UCEC	Cyclin-B1 →	+0.640	+2.874	<.001	<.001	3	4
UCEC	eEF2 →	+0.278	+1.662	.002	.009	3	4
UCEC	Annexin_VII →	-0.103	-1.137	.004	.008	3	4
LUSC	53BP1 →	+0.521	+2.321	.002	.033	2	4
UCEC	Di-Ras3 →	-0.200	-1.750	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 107 associations by consensus.

FoxM1 by RET expression — STAD

Explore this box plot interactively →