RET

Across TCGA pan-cancer cohorts, RET RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated RET data layer compared with 9 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher RET RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RET expression acts as an unfavorable survival marker, although some lineages such as THCA and READ show a favorable association.

UCEC, KIRC, and ACC are the cancer types where RET RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.783	0.889	<.001	82	view →
KIRC	DFS	Quartile	II,III,IV	0.406	0.631	.002	79	view →
ACC	OS	Median	II,III,IV	0.358	0.922	<.001	59	view →
HNSC	OS	Tertile	All	0.619	0.752	.005	51	view →
STAD	OS	Median	III,IV	0.543	0.713	.001	39	view →
THCA	DFS	Quartile	All	0.922	0.663	<.001	30	view →
READ	DFS	Median	III,IV	0.620	0.376	.020	27	view →
DLBC	DFS	Quartile	All	0.344	1.000	.002	23	view →
LGG	OS	Tertile	All	0.944	0.833	<.001	22	view →
PAAD	DFS	Tertile	All	0.586	0.424	.018	18	view →
KIRP	DFS	Median	II,III,IV	0.262	0.712	.009	18	view →
CESC	DFS	Median	All	0.452	0.640	.021	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

RET–UCEC (DFS)

Open the UCEC breakdown →