RET

Across TCGA pan-cancer cohorts, RET RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of RET’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RET RNA is repressed in tumor relative to normal tissue. In most cancer types RET is over-expressed in tumor, although a few such as KIRC and LIHC show the opposite, repressed pattern.

KIRC, LIHC, and HNSC are the cancer types where RET tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RET RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.808	<.001	11	view →
LIHC	All	III,IV	−1.239	<.001	9	view →
HNSC	All	II,III,IV	+0.638	<.001	9	view →
BRCA	All	III,IV	+2.129	<.001	6	view →
KIRP	Male	All	−0.695	<.001	6	view →
COAD	Female	III,IV	−0.936	.002	5	view →
BLCA	Female	All	−0.230	.026	3	view →
STAD	Female	All	−1.384	.017	2	view →
READ	All	All	−1.034	.035	2	view →
PRAD	All	All	+0.930	<.001	2	view →
LUSC	Female	All	+0.575	.030	2	view →
LUAD	All	All	+0.551	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

RET–KIRC

Open the KIRC breakdown →