RET

Across TCGA cell cohorts, RET RNA expression is significantly associated with the go_rna of many other GO terms, with 3,113 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible RET-associated GO terms across cancer lineages are Positive regulation of metanephros development, Regulation of metanephric glomerulus development, and Positive regulation of metanephric glomerulus development. Each is linked with RET in more than 15 cancer types. Because this analysis shows association rather than direction, both RET-to-partner and partner-to-RET results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of metanephros development grouped by RET-low versus RET-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RET→partner) and Y-score (partner→RET) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Positive regulation of metanephros development →	+1.449	+3.078	<.001	<.001	3	16
BREAST	Regulation of metanephric glomerulus development →	+1.449	+3.078	<.001	<.001	3	16
BREAST	Positive regulation of metanephric glomerulus development →	+1.449	+3.078	<.001	<.001	3	16
BLOOD_Myeloma	Negative regulation of myoblast fusion →	+0.082	+0.146	.004	.002	3	11
SOFT_TISSUE	Purine ribonucleoside triphosphate metabolic process →	+0.063	+0.466	<.001	<.001	3	10
STOMACH	Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand →	-0.221	-0.446	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,113 associations by consensus.

Positive regulation of metanephros development by RET expression — BREAST

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