RET

Across TCGA cell cohorts, RET mutation is significantly associated with the RNA expression of many other genes, with 150 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RET-associated genes across cancer lineages are ACSM6, MUC17, and VAPA. Each is linked with RET in more than 1 cancer types. Because this analysis shows association rather than direction, both RET-to-partner and partner-to-RET results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACSM6 grouped by RET-low versus RET-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RET→partner) and Y-score (partner→RET) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACSM6 →	+0.015	+2.584	.001	.002	3	2
LUNG_SCLC	MUC17 →	+0.009	+3.523	<.001	.008	3	2
LARGE_INTESTINE	VAPA →	+0.477	+3.169	.009	.009	3	1
LARGE_INTESTINE	METTL4 →	+0.594	+3.067	.002	.009	3	1
LARGE_INTESTINE	FZD3 →	+0.795	+3.237	.001	.003	3	1
LARGE_INTESTINE	TNFRSF10A →	+0.892	+3.386	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 150 associations by consensus.

ACSM6 by RET expression — LARGE_INTESTINE

Explore this box plot interactively →