REST

Across TCGA patient cohorts, REST mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible REST-associated genes across cancer lineages are ATM, MEK1, and Caspase-7-cleavedD198. Each is linked with REST in more than 2 cancer types. Because this analysis shows association rather than direction, both REST-to-partner and partner-to-REST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by REST-low versus REST-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REST→partner) and Y-score (partner→REST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.532	-1.938	<.001	.001	3	3
UCEC	MEK1 →	+0.391	+2.263	.001	<.001	3	2
COAD	Caspase-7-cleavedD198 →	+1.739	+3.178	<.001	.010	3	2
UCEC	eIF4E →	+0.155	+2.321	.025	.005	3	2
UCEC	ERK2 →	+0.183	+1.678	.003	.019	3	2
UCEC	mTOR_pS2448 →	-0.145	-2.980	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

ATM by REST expression — UCEC

Explore this box plot interactively →