REST

Across TCGA cell cohorts, REST RNA expression is significantly associated with the go_rna of many other GO terms, with 4,999 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible REST-associated GO terms across cancer lineages are RNA destabilization, mRNA destabilization, and Positive regulation of organelle assembly. Each is linked with REST in more than 17 cancer types. Because this analysis shows association rather than direction, both REST-to-partner and partner-to-REST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA destabilization grouped by REST-low versus REST-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (REST→partner) and Y-score (partner→REST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	RNA destabilization →	+0.081	+0.710	<.001	.001	3	18
STOMACH	mRNA destabilization →	+0.083	+0.773	<.001	.002	3	17
SOFT_TISSUE	Positive regulation of organelle assembly →	+0.064	+0.858	<.001	<.001	3	16
STOMACH	Positive regulation of mRNA catabolic process →	+0.067	+0.680	<.001	.002	3	16
STOMACH	Positive regulation of mRNA metabolic process →	+0.065	+0.617	.002	.007	2	15
URINARY_TRACT	Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay →	+0.086	+0.658	.006	.008	2	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,999 associations by consensus.

RNA destabilization by REST expression — URINARY_TRACT

Explore this box plot interactively →