REST

Across TCGA cell cohorts, REST mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible REST-associated genes across cancer lineages are TMEM95, CFHR2, and OR4F6. Each is linked with REST in more than 1 cancer types. Because this analysis shows association rather than direction, both REST-to-partner and partner-to-REST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM95 grouped by REST-low versus REST-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REST→partner) and Y-score (partner→REST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TMEM95 →	+0.034	+4.977	<.001	.007	3	2
OVARY	CFHR2 →	+0.119	+4.450	<.001	.004	3	2
BLOOD_Lymphoma	OR4F6 →	+0.019	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	ZNF705G →	+0.006	+4.867	<.001	.009	3	1
SKIN	KRTAP4-6 →	+0.046	+5.415	<.001	.004	3	1
LUNG_NSCLC_LUAD	DMRTB1 →	+0.005	+4.472	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

TMEM95 by REST expression — SKIN

Explore this box plot interactively →