REG3G

Across TCGA patient cohorts, REG3G mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible REG3G-associated genes across cancer lineages are Cyclin-B1, 4E-BP1, and MSH6. Each is linked with REG3G in more than 3 cancer types. Because this analysis shows association rather than direction, both REG3G-to-partner and partner-to-REG3G results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by REG3G-low versus REG3G-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REG3G→partner) and Y-score (partner→REG3G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	Cyclin-B1 →	+0.362	+1.594	.041	.043	3	4
UCEC	4E-BP1 →	+0.350	+2.199	.003	.033	3	3
LUSC	MSH6 →	+0.363	+2.816	.023	.001	3	2
LUSC	p70-S6K →	+0.226	+3.321	.018	.009	3	2
SKCM	INPP4B →	-0.241	-3.442	.011	.005	3	2
UCEC	GAPDH →	+0.621	+3.169	.008	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Cyclin-B1 by REG3G expression — LUSC

Explore this box plot interactively →