REG3G

Across TCGA pan-cancer cohorts, REG3G RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of REG3G’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where REG3G RNA is more highly expressed in tumor relative to normal tissue. In most cancer types REG3G is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

KIRP, KICH, and BRCA are the cancer types where REG3G tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in REG3G RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Male	All	+2.194	.001	6	view →
KICH	All	All	−0.505	.003	5	view →
BRCA	Female	All	−0.011	.001	4	view →
STAD	Male	All	−0.461	.027	3	view →
LIHC	All	All	+0.044	.016	2	view →
COAD	All	II,III,IV	+0.243	.021	1	view →
READ	All	All	+0.198	.022	1	view →
THCA	All	All	+0.011	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

REG3G–KIRP

Open the KIRP breakdown →