REG3G

Across TCGA pan-cancer cohorts, REG3G RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated REG3G data layer compared with 7 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher REG3G RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated REG3G expression acts as an unfavorable survival marker, although some lineages such as CHOL and READ show a favorable association.

CESC, LUAD, and UVM are the cancer types where REG3G RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Tertile	II,III,IV	0.505	0.808	.001	72	view →
LUAD	DFS	Tertile	IV	0.342	0.893	<.001	72	view →
UVM	DFS	Quartile	All	0.485	0.888	<.001	64	view →
UCEC	OS	Tertile	All	0.860	0.939	.001	54	view →
DLBC	OS	Tertile	All	0.546	0.875	.014	39	view →
CHOL	DFS	Tertile	All	0.856	0.322	.013	27	view →
READ	DFS	Tertile	All	0.853	0.448	.014	23	view →
ACC	DFS	Quartile	All	0.699	0.266	.002	21	view →
GBM	DFS	Tertile	All	0.084	0.305	.002	18	view →
KIRP	DFS	Quartile	II,III,IV	0.118	0.653	.036	10	view →
PAAD	OS	Median	II,III,IV	0.303	0.480	.034	9	view →
ESCA	OS	Tertile	II,III,IV	0.464	1.000	.009	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

REG3G–CESC (DFS)

Open the CESC breakdown →