REG3G

Across TCGA cell cohorts, REG3G mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible REG3G-associated genes across cancer lineages are GP9, GAGE12J, and CFAP97D2. Each is linked with REG3G in more than 1 cancer types. Because this analysis shows association rather than direction, both REG3G-to-partner and partner-to-REG3G results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GP9 grouped by REG3G-low versus REG3G-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REG3G→partner) and Y-score (partner→REG3G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	GP9 →	+0.228	+4.736	<.001	.009	3	2
LUNG_NSCLC_LUSC	GAGE12J →	+0.266	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	CFAP97D2 →	+0.020	+4.643	<.001	.008	3	1
SKIN	CELA2B →	+0.049	+4.467	<.001	.004	3	1
LARGE_INTESTINE	TP53TG3E →	+0.016	+4.930	<.001	.001	3	1
LUNG_SCLC	PF4V1 →	+1.195	+3.762	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

GP9 by REG3G expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →