REG1B

Across TCGA patient cohorts, REG1B mutation is significantly associated with the RNA expression of many other genes, with 3,674 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible REG1B-associated genes across cancer lineages are NUF2, RCCD1, and BUB1B. Each is linked with REG1B in more than 4 cancer types. Because this analysis shows association rather than direction, both REG1B-to-partner and partner-to-REG1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NUF2 grouped by REG1B-low versus REG1B-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REG1B→partner) and Y-score (partner→REG1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	NUF2 →	+0.728	+3.193	.003	.009	3	4
HNSC	RCCD1 →	+0.587	+3.584	.001	.002	3	4
UCEC	BUB1B →	+0.879	+2.818	.002	.001	3	4
UCEC	FBXO22 →	+0.697	+3.939	<.001	<.001	3	4
UCEC	CKAP2L →	+0.923	+3.917	<.001	<.001	3	4
UCEC	BUB1 →	+0.740	+2.850	.008	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,674 associations by consensus.

NUF2 by REG1B expression — HNSC

Explore this box plot interactively →