REG1B

Across TCGA pan-cancer cohorts, REG1B RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated REG1B data layer compared with 4 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher REG1B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated REG1B expression acts as an unfavorable survival marker, although some lineages such as STAD and READ show a favorable association.

ACC, UVM, and SKCM are the cancer types where REG1B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Tertile	II,III,IV	0.082	0.487	.001	75	view →
UVM	DFS	Tertile	All	0.310	0.781	.004	54	view →
SKCM	DFS	Tertile	IV	0.036	0.433	<.001	36	view →
LUAD	DFS	Tertile	IV	0.109	0.714	.001	36	view →
CESC	DFS	Tertile	All	0.259	0.574	<.001	30	view →
SCLC	OS	Tertile	All	0.055	0.653	<.001	27	view →
LGG	OS	Tertile	All	0.834	0.908	.001	21	view →
STAD	DFS	Tertile	IV	0.476	0.087	.017	17	view →
PAAD	OS	Tertile	All	0.169	0.592	.002	15	view →
READ	OS	Median	II,III,IV	1.000	0.851	.010	12	view →
ESCA	OS	Median	All	0.617	1.000	.009	12	view →
KIRC	DFS	Quartile	IV	0.640	0.233	.021	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

REG1B–ACC (DFS)

Open the ACC breakdown →