REG1B

Across TCGA pan-cancer cohorts, REG1B RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of REG1B’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where REG1B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types REG1B is over-expressed in tumor, although a few such as STAD show the opposite, repressed pattern.

COAD, KIRC, and LIHC are the cancer types where REG1B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in REG1B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	+3.705	<.001	9	view →
KIRC	All	All	+0.780	<.001	9	view →
LIHC	All	III,IV	+0.303	.034	4	view →
READ	Female	All	+3.624	.001	2	view →
STAD	Male	IV	−0.480	.017	2	view →
CHOL	All	All	+0.504	.031	1	view →
HNSC	All	All	+0.012	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

REG1B–COAD

Open the COAD breakdown →