REG1B

Across TCGA patient cohorts, REG1B mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible REG1B-associated genes across cancer lineages are Transglutaminase, TFRC, and PI3K-p85. Each is linked with REG1B in more than 2 cancer types. Because this analysis shows association rather than direction, both REG1B-to-partner and partner-to-REG1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transglutaminase grouped by REG1B-low versus REG1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REG1B→partner) and Y-score (partner→REG1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Transglutaminase →	-0.507	-3.321	.032	.010	3	3
SKCM	TFRC →	+0.516	+2.807	.011	.002	3	3
LUSC	PI3K-p85 →	-0.122	-2.445	.040	.018	3	2
LUSC	PREX1 →	-0.172	-3.445	.017	.005	3	2
LUSC	Rb_pS807_S811 →	+0.554	+1.816	<.001	.015	3	2
LUSC	4E-BP1_pS65 →	+0.184	+2.331	.003	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

Transglutaminase by REG1B expression — UCEC

Explore this box plot interactively →