REG1B

Across TCGA cell cohorts, REG1B mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible REG1B-associated genes across cancer lineages are OR4C6, CYP26C1, and OTUD6A. Each is linked with REG1B in more than 1 cancer types. Because this analysis shows association rather than direction, both REG1B-to-partner and partner-to-REG1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4C6 grouped by REG1B-low versus REG1B-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REG1B→partner) and Y-score (partner→REG1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR4C6 →	+0.146	+3.578	.009	.006	3	1
SKIN	CYP26C1 →	+0.116	+3.906	.004	.005	3	1
BLOOD_Lymphoma	OTUD6A →	+0.113	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	SMIM9 →	+0.200	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	LYPD4 →	+0.128	+4.867	<.001	.009	3	1
LUNG_NSCLC_LUAD	LUZP4 →	+0.035	+3.536	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

OR4C6 by REG1B expression — SKIN

Explore this box plot interactively →