RECQL

Across TCGA cell cohorts, RECQL mutation is significantly associated with the mutation status of many other genes, with 3,991 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RECQL-associated genes across cancer lineages are WDR70, IL1R2, and PARD3B. Each is linked with RECQL in more than 2 cancer types. Because this analysis shows association rather than direction, both RECQL-to-partner and partner-to-RECQL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WDR70 grouped by RECQL-low versus RECQL-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RECQL→partner) and Y-score (partner→RECQL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	WDR70 →	+4.429	+5.247	.005	.005	1	3
LARGE_INTESTINE	IL1R2 →	+2.614	+3.733	<.001	<.001	1	3
LARGE_INTESTINE	PARD3B →	+2.807	+3.857	<.001	<.001	1	3
LARGE_INTESTINE	MDC1 →	+2.584	+3.182	<.001	<.001	1	3
SKIN	GTPBP1 →	+5.824	+5.824	.002	.002	1	2
SKIN	TBL1X →	+4.824	+5.392	.004	.004	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,991 associations by consensus.

WDR70 by RECQL expression — BLOOD_Lymphoma

Explore this box plot interactively →