RECQL

Across TCGA pan-cancer cohorts, RECQL RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated RECQL data layer compared with 6 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher RECQL RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RECQL expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCS show a favorable association.

MESO, KIRC, and BLCA are the cancer types where RECQL RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Quartile	III,IV	0.229	0.507	.002	81	view →
KIRC	DFS	Median	All	0.749	0.493	<.001	78	view →
BLCA	DFS	Median	All	0.447	0.570	.001	67	view →
UVM	OS	Quartile	III,IV	0.281	1.000	.001	63	view →
LGG	OS	Median	All	0.744	0.885	<.001	43	view →
ACC	DFS	Tertile	All	0.473	0.796	.001	35	view →
LUSC	DFS	Median	III,IV	0.339	0.968	<.001	28	view →
UCS	OS	Tertile	IV	0.883	0.296	.024	24	view →
LIHC	OS	Median	All	0.726	0.826	.007	24	view →
PAAD	OS	Quartile	All	0.427	0.728	.003	21	view →
SCLC	DFS	Quartile	III,IV	0.570	0.147	.015	20	view →
CESC	OS	Tertile	All	0.848	0.932	.008	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

RECQL–MESO (DFS)

Open the MESO breakdown →