RDX

Across TCGA patient cohorts, RDX mutation is significantly associated with the RNA expression of many other genes, with 4,055 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RDX-associated genes across cancer lineages are RN7SL248P, KRT17P2, and RNY4P14. Each is linked with RDX in more than 1 cancer types. Because this analysis shows association rather than direction, both RDX-to-partner and partner-to-RDX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by RDX-low versus RDX-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RDX→partner) and Y-score (partner→RDX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RN7SL248P →	+0.130	+5.786	<.001	.001	3	2
READ	KRT17P2 →	+0.028	+4.202	.006	.008	3	2
READ	RNY4P14 →	+0.336	+4.421	<.001	.009	3	2
BLCA	PABPC1P13 →	+0.028	+6.147	<.001	.002	3	2
READ	RN7SL25P →	+0.114	+4.925	<.001	.004	3	2
CESC	LINC01035 →	+0.053	+4.669	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,055 associations by consensus.

RN7SL248P by RDX expression — BRCA

Explore this box plot interactively →