RDH12

Across TCGA cell cohorts, RDH12 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RDH12-associated genes across cancer lineages are CRISP2, USP29, and CCDC42. Each is linked with RDH12 in more than 1 cancer types. Because this analysis shows association rather than direction, both RDH12-to-partner and partner-to-RDH12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CRISP2 grouped by RDH12-low versus RDH12-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RDH12→partner) and Y-score (partner→RDH12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CRISP2 →	+0.025	+4.467	<.001	.004	3	1
LARGE_INTESTINE	USP29 →	+0.009	+4.415	<.001	.007	3	1
LARGE_INTESTINE	CCDC42 →	+0.044	+4.095	<.001	.009	3	1
LARGE_INTESTINE	PATE1 →	+0.009	+4.415	<.001	.007	3	1
LARGE_INTESTINE	OR52N5 →	+0.067	+5.022	<.001	.002	3	1
LARGE_INTESTINE	CCT8L2 →	+0.005	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

CRISP2 by RDH12 expression — LARGE_INTESTINE

Explore this box plot interactively →