RDH12

Across TCGA pan-cancer cohorts, RDH12 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of RDH12’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where RDH12 RNA is repressed in tumor relative to normal tissue. In most cancer types RDH12 is over-expressed in tumor, although a few such as KIRP and HNSC show the opposite, repressed pattern.

KIRP, HNSC, and COAD are the cancer types where RDH12 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RDH12 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Male	III,IV	−2.735	<.001	11	view →
HNSC	All	III,IV	−1.532	.003	10	view →
COAD	Female	All	+0.299	<.001	10	view →
STAD	Male	II,III,IV	−2.050	<.001	9	view →
THCA	All	III,IV	−1.204	<.001	9	view →
KICH	All	II,III,IV	−1.904	<.001	6	view →
KIRC	Male	All	−1.401	<.001	6	view →
LUAD	All	All	−0.143	.005	5	view →
LUSC	Male	All	+0.812	<.001	4	view →
LIHC	Female	All	+0.665	.015	4	view →
BRCA	All	All	+0.276	<.001	4	view →
BLCA	Male	III,IV	+1.591	.028	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

RDH12–KIRP

Open the KIRP breakdown →