RCE1

Across TCGA patient cohorts, RCE1 mutation is significantly associated with the RNA expression of many other genes, with 797 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RCE1-associated genes across cancer lineages are RNU6-1077P, KRTAP3-4P, and RPL36P20. Each is linked with RCE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RCE1-to-partner and partner-to-RCE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1077P grouped by RCE1-low versus RCE1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RCE1→partner) and Y-score (partner→RCE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU6-1077P →	+0.447	+4.211	.003	.009	3	2
LUSC	KRTAP3-4P →	+0.121	+5.438	.001	.002	3	2
CESC	RPL36P20 →	+0.248	+4.760	<.001	.003	3	1
CESC	PPIAP27 →	+0.197	+4.551	.004	.004	3	1
CESC	MIR3137 →	+0.303	+4.539	<.001	.008	3	1
CESC	NTF6G →	+0.059	+5.342	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 797 associations by consensus.

RNU6-1077P by RCE1 expression — LUSC

Explore this box plot interactively →