RCE1

Across TCGA pan-cancer cohorts, RCE1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of RCE1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RCE1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RCE1 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, BLCA, and LIHC are the cancer types where RCE1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RCE1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.030	<.001	12	view →
BLCA	All	III,IV	+1.009	<.001	11	view →
LIHC	Female	II,III,IV	+1.293	<.001	9	view →
STAD	Male	II,III,IV	+1.288	<.001	9	view →
COAD	Female	All	+0.629	<.001	8	view →
LUAD	Male	All	+0.466	<.001	8	view →
LUSC	Male	III,IV	+1.464	<.001	7	view →
KICH	All	All	−0.822	<.001	6	view →
BRCA	All	II,III,IV	+0.350	<.001	6	view →
CHOL	Male	All	+2.946	<.001	3	view →
ESCA	All	All	+0.947	.001	3	view →
KIRP	All	IV	+0.967	.035	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

RCE1–HNSC

Open the HNSC breakdown →