RCC1L

Across TCGA patient cohorts, RCC1L mutation is significantly associated with the RNA expression of many other genes, with 197 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RCC1L-associated genes across cancer lineages are OR5K1, TRAJ57, and SNORD90. Each is linked with RCC1L in more than 1 cancer types. Because this analysis shows association rather than direction, both RCC1L-to-partner and partner-to-RCC1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5K1 grouped by RCC1L-low versus RCC1L-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RCC1L→partner) and Y-score (partner→RCC1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	OR5K1 →	+0.015	+3.990	<.001	.009	3	2
UCEC	TRAJ57 →	+0.554	+2.734	<.001	.008	3	2
UCEC	SNORD90 →	+0.423	+2.670	<.001	.009	3	2
UCEC	MORF4L1P6 →	+0.086	+4.245	<.001	.006	3	2
UCEC	MTCO1P35 →	+0.735	+3.399	<.001	.005	3	2
CESC	RNU6-1066P →	+0.610	+5.418	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 197 associations by consensus.

OR5K1 by RCC1L expression — SKCM

Explore this box plot interactively →