RCC1L

Across TCGA pan-cancer cohorts, RCC1L RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated RCC1L data layer compared with 2 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher RCC1L RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RCC1L expression acts as an unfavorable survival marker, although some lineages such as ESCA and UCEC show a favorable association.

KICH, LGG, and UVM are the cancer types where RCC1L RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Tertile	All	0.505	1.000	<.001	90	view →
LGG	OS	Median	All	0.349	0.553	<.001	54	view →
UVM	DFS	Tertile	II,III,IV	0.281	0.757	<.001	46	view →
LIHC	OS	Tertile	All	0.590	0.784	<.001	46	view →
LUAD	OS	Median	All	0.636	0.732	.002	35	view →
MESO	DFS	Median	All	0.285	0.439	.011	33	view →
CESC	OS	Median	IV	0.320	0.779	<.001	26	view →
ACC	DFS	Median	All	0.281	0.752	.002	20	view →
GBM	OS	Tertile	All	0.312	0.538	<.001	17	view →
COAD	DFS	Quartile	II,III,IV	0.696	0.860	.001	17	view →
PRAD	DFS	Tertile	All	0.697	0.883	.007	16	view →
ESCA	DFS	Median	II,III,IV	1.000	0.399	.013	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

RCC1L–KICH (OS)

Open the KICH breakdown →