RCC1L

Across TCGA pan-cancer cohorts, RCC1L RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of RCC1L’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RCC1L RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RCC1L is over-expressed in tumor.

HNSC, COAD, and LIHC are the cancer types where RCC1L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RCC1L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.703	<.001	11	view →
COAD	Female	II,III,IV	+0.677	<.001	11	view →
LIHC	Female	II,III,IV	+1.080	<.001	9	view →
LUAD	Female	III,IV	+0.793	<.001	9	view →
STAD	Male	II,III,IV	+0.973	<.001	8	view →
LUSC	Male	II,III,IV	+0.834	<.001	8	view →
KIRP	All	All	+0.301	.002	8	view →
BLCA	Female	All	+0.671	.001	6	view →
CHOL	Male	All	+1.096	<.001	5	view →
THCA	All	All	+0.162	.003	4	view →
READ	All	III,IV	+0.750	.047	2	view →
ESCA	All	All	+0.686	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

RCC1L–HNSC

Open the HNSC breakdown →