RCC1L

Across TCGA patient cohorts, RCC1L mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RCC1L-associated genes across cancer lineages are Caspase-7-cleavedD198, AR, and VHL. Each is linked with RCC1L in more than 1 cancer types. Because this analysis shows association rather than direction, both RCC1L-to-partner and partner-to-RCC1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by RCC1L-low versus RCC1L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RCC1L→partner) and Y-score (partner→RCC1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.729	+2.827	.033	.035	3	2
UCEC	AR →	-0.471	-3.000	.029	.037	3	1
UCEC	VHL →	-1.030	-3.000	.008	.037	3	1
UCEC	EGFR_pY1068 →	-0.384	-3.000	.008	.037	1	2

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Caspase-7-cleavedD198 by RCC1L expression — UCEC

Explore this box plot interactively →