RCC1L

Across TCGA cell cohorts, RCC1L mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RCC1L-associated genes across cancer lineages are LY6G6F, LGI1, and C1QL2. Each is linked with RCC1L in more than 1 cancer types. Because this analysis shows association rather than direction, both RCC1L-to-partner and partner-to-RCC1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LY6G6F grouped by RCC1L-low versus RCC1L-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RCC1L→partner) and Y-score (partner→RCC1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	LY6G6F →	+0.036	+4.643	<.001	.008	3	1
BLOOD_Leukemia	LGI1 →	+0.129	+5.539	<.001	.003	3	1
BLOOD_Leukemia	C1QL2 →	+0.019	+4.922	<.001	.009	3	1
BLOOD_Leukemia	DRD3 →	+0.019	+5.201	<.001	.006	3	1
BLOOD_Leukemia	SYCN →	+0.071	+5.539	<.001	.003	3	1
BLOOD_Leukemia	SPPL2C →	+0.012	+4.922	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

LY6G6F by RCC1L expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →