RCC1

Across TCGA patient cohorts, RCC1 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RCC1-associated genes across cancer lineages are MEK1, TFRC, and eIF4E. Each is linked with RCC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RCC1-to-partner and partner-to-RCC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by RCC1-low versus RCC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RCC1→partner) and Y-score (partner→RCC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.396	+2.321	.031	.035	3	2
UCEC	TFRC →	+0.615	+2.321	.021	.035	3	2
UCEC	eIF4E →	+0.226	+3.459	.032	.005	3	1
UCEC	p70-S6K →	+0.211	+3.486	.029	.002	3	1
UCEC	PDK1_pS241 →	+0.205	+3.169	.016	.019	3	1
UCEC	PDK1 →	+0.132	+2.321	.014	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

MEK1 by RCC1 expression — UCEC

Explore this box plot interactively →