RCC1

Across TCGA pan-cancer cohorts, RCC1 RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated RCC1 data layer compared with 5 for mutation status and 8 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher RCC1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RCC1 expression acts as an unfavorable survival marker, although some lineages such as READ and UCEC show a favorable association.

KIRP, ACC, and LIHC are the cancer types where RCC1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.582	0.783	<.001	148	view →
ACC	OS	Median	All	0.781	0.957	<.001	99	view →
LIHC	OS	Median	All	0.599	0.762	<.001	98	view →
KICH	DFS	Median	III,IV	0.308	0.942	.001	81	view →
LGG	DFS	Median	All	0.664	0.816	<.001	54	view →
MESO	OS	Tertile	All	0.356	0.668	.001	52	view →
SARC	DFS	Median	All	0.504	0.714	<.001	52	view →
READ	DFS	Quartile	II,III,IV	0.963	0.275	.001	52	view →
KIRC	OS	Median	II,III,IV	0.713	0.891	<.001	49	view →
PAAD	DFS	Quartile	All	0.208	0.597	.001	48	view →
SKCM	OS	Tertile	II,III,IV	0.282	0.447	<.001	42	view →
CESC	OS	Quartile	IV	0.235	0.814	.022	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

RCC1–KIRP (OS)

Open the KIRP breakdown →