RCC1

Across TCGA cell cohorts, RCC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,816 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible RCC1-associated GO terms across cancer lineages are DNA replication checkpoint signaling, Double-strand break repair via break-induced replication, and DNA strand elongation. Each is linked with RCC1 in more than 17 cancer types. Because this analysis shows association rather than direction, both RCC1-to-partner and partner-to-RCC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication checkpoint signaling grouped by RCC1-low versus RCC1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RCC1→partner) and Y-score (partner→RCC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA replication checkpoint signaling →	+0.266	+1.448	<.001	<.001	3	18
BONE	Double-strand break repair via break-induced replication →	+0.290	+1.668	<.001	<.001	3	17
BONE	DNA strand elongation →	+0.165	+0.976	.002	.005	3	16
BONE	Nuclear DNA replication →	+0.187	+1.263	<.001	<.001	3	16
OESOPHAGUS	Mitotic DNA replication checkpoint signaling →	+0.209	+0.905	.001	.001	3	16
BONE	Cell cycle DNA replication →	+0.179	+1.154	<.001	.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,816 associations by consensus.

DNA replication checkpoint signaling by RCC1 expression — BONE

Explore this box plot interactively →