RC3H2

Across TCGA cell cohorts, RC3H2 mutation is significantly associated with the RNA expression of many other genes, with 640 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RC3H2-associated genes across cancer lineages are PRIMPOL, APCS, and KRTAP10-1. Each is linked with RC3H2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RC3H2-to-partner and partner-to-RC3H2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRIMPOL grouped by RC3H2-low versus RC3H2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RC3H2→partner) and Y-score (partner→RC3H2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PRIMPOL →	+0.597	+3.628	.001	<.001	3	2
KIDNEY	APCS →	+0.033	+5.000	<.001	.005	3	1
KIDNEY	KRTAP10-1 →	+0.020	+5.000	<.001	.005	3	1
BLOOD_Lymphoma	AVP →	+0.031	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	DCAF12L1 →	+0.012	+4.867	<.001	.009	3	1
STOMACH	SSX7 →	+0.433	+5.285	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 640 associations by consensus.

PRIMPOL by RC3H2 expression — LARGE_INTESTINE

Explore this box plot interactively →