RC3H2

Across TCGA pan-cancer cohorts, RC3H2 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of RC3H2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RC3H2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RC3H2 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, THCA, and LIHC are the cancer types where RC3H2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RC3H2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.188	<.001	12	view →
THCA	All	II,III,IV	−0.588	<.001	8	view →
LIHC	All	II,III,IV	+0.563	<.001	7	view →
CHOL	All	All	+1.316	<.001	5	view →
KICH	All	All	−0.726	<.001	5	view →
STAD	All	II,III,IV	+0.700	.004	4	view →
COAD	Male	All	+0.371	.009	4	view →
KIRP	Male	All	−0.551	.001	2	view →
PRAD	All	All	+0.233	.042	2	view →
ESCA	All	All	+0.642	.011	1	view →
LUSC	All	All	+0.188	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

RC3H2–HNSC

Open the HNSC breakdown →