RBPJL

Across TCGA patient cohorts, RBPJL mutation is significantly associated with the RNA expression of many other genes, with 1,813 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBPJL-associated genes across cancer lineages are RN7SL561P, RN7SKP112, and ELOBP3. Each is linked with RBPJL in more than 2 cancer types. Because this analysis shows association rather than direction, both RBPJL-to-partner and partner-to-RBPJL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL561P grouped by RBPJL-low versus RBPJL-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBPJL→partner) and Y-score (partner→RBPJL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RN7SL561P →	+0.113	+4.122	<.001	.008	3	3
CESC	RN7SKP112 →	+0.119	+4.669	<.001	.007	3	2
CESC	ELOBP3 →	+0.157	+6.397	.004	<.001	3	2
READ	RNU6-1274P →	+0.403	+4.925	<.001	.004	3	2
READ	RNU6-893P →	+0.733	+4.445	<.001	.005	3	2
READ	ATF4P2 →	+0.131	+5.179	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,813 associations by consensus.

RN7SL561P by RBPJL expression — BLCA

Explore this box plot interactively →