RBPJL

Across TCGA pan-cancer cohorts, RBPJL RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated RBPJL data layer compared with 3 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher RBPJL RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RBPJL expression acts as an unfavorable survival marker, although some lineages such as UVM and UCEC show a favorable association.

KIRC, UVM, and UCEC are the cancer types where RBPJL RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.546	0.698	<.001	113	view →
UVM	OS	Median	All	0.808	0.473	.003	88	view →
UCEC	OS	Quartile	IV	0.858	0.349	.003	24	view →
MESO	OS	Median	All	0.264	0.700	.003	21	view →
THCA	OS	Median	II,III,IV	0.957	1.000	.006	17	view →
CHOL	OS	Tertile	II,III,IV	0.948	0.233	.008	13	view →
LUSC	DFS	Tertile	III,IV	0.474	0.910	.025	13	view →
BLCA	OS	Quartile	All	0.553	0.363	.014	12	view →
LAML	DFS	Median	All	0.502	0.283	.030	12	view →
READ	OS	Tertile	II,III,IV	1.000	0.841	.017	11	view →
LGG	DFS	Tertile	All	0.661	0.798	.009	9	view →
PAAD	OS	Median	II,III,IV	0.296	0.497	.015	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

RBPJL–KIRC (OS)

Open the KIRC breakdown →