RBPJ

Across TCGA patient cohorts, RBPJ mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBPJ-associated genes across cancer lineages are FoxM1, Notch1, and Chk2_pT68. Each is linked with RBPJ in more than 1 cancer types. Because this analysis shows association rather than direction, both RBPJ-to-partner and partner-to-RBPJ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by RBPJ-low versus RBPJ-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBPJ→partner) and Y-score (partner→RBPJ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.177	+1.247	.044	.045	3	2
UCEC	Notch1 →	+0.120	+1.598	.012	.040	3	2
UCEC	Chk2_pT68 →	-0.131	-3.558	.038	.002	3	2
UCEC	14-3-3_beta →	-0.096	-2.780	.005	.003	3	1
UCEC	eEF2 →	+0.293	+2.115	.016	.017	3	1
UCEC	A-Raf_pS299 →	-0.103	-3.459	.011	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

FoxM1 by RBPJ expression — UCEC

Explore this box plot interactively →