RBPJ

Across TCGA cell cohorts, RBPJ mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RBPJ-associated genes across cancer lineages are CASP14, SEC14L3, and MSGN1. Each is linked with RBPJ in more than 1 cancer types. Because this analysis shows association rather than direction, both RBPJ-to-partner and partner-to-RBPJ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CASP14 grouped by RBPJ-low versus RBPJ-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBPJ→partner) and Y-score (partner→RBPJ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CASP14 →	+1.411	+3.695	.009	.005	3	1
LARGE_INTESTINE	SEC14L3 →	+0.023	+3.994	.003	.002	3	1
LARGE_INTESTINE	MSGN1 →	+0.056	+3.345	.007	.007	3	1
LARGE_INTESTINE	SAXO1 →	+0.040	+3.556	.006	.007	3	1
LARGE_INTESTINE	OR2AT4 →	+0.015	+3.196	.006	.007	3	1
LARGE_INTESTINE	PRND →	+0.025	+3.878	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

CASP14 by RBPJ expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →