RBM14-RBM4

Across TCGA cell cohorts, RBM14-RBM4 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RBM14-RBM4-associated genes across cancer lineages are C7orf77, MYF6, and GKN1. Each is linked with RBM14-RBM4 in more than 1 cancer types. Because this analysis shows association rather than direction, both RBM14-RBM4-to-partner and partner-to-RBM14-RBM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C7orf77 grouped by RBM14-RBM4-low versus RBM14-RBM4-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBM14-RBM4→partner) and Y-score (partner→RBM14-RBM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	C7orf77 →	+0.072	+5.662	<.001	.002	3	1
LARGE_INTESTINE	MYF6 →	+0.014	+4.415	<.001	.007	3	1
LARGE_INTESTINE	GKN1 →	+0.045	+4.095	.002	.009	3	1
LARGE_INTESTINE	OR1L6 →	+0.027	+5.022	<.001	.002	3	1
LARGE_INTESTINE	SLC15A5 →	+0.017	+4.415	<.001	.007	3	1
OVARY	OR1L3 →	+0.034	+4.029	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

C7orf77 by RBM14-RBM4 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →