RBM14-RBM4

Across TCGA pan-cancer cohorts, RBM14-RBM4 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of RBM14-RBM4’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where RBM14-RBM4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RBM14-RBM4 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

COAD, THCA, and HNSC are the cancer types where RBM14-RBM4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RBM14-RBM4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	III,IV	+0.428	<.001	11	view →
THCA	Male	III,IV	−0.441	<.001	10	view →
HNSC	Male	III,IV	+0.463	<.001	9	view →
LUSC	All	II,III,IV	+0.391	<.001	7	view →
BRCA	All	II,III,IV	+0.364	<.001	6	view →
LIHC	All	II,III,IV	+0.218	<.001	6	view →
STAD	Male	II,III,IV	+0.498	.001	4	view →
KIRC	All	All	+0.112	.003	4	view →
LUAD	All	All	+0.279	.002	3	view →
CHOL	All	All	+0.820	.006	2	view →
READ	Female	All	+0.315	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

RBM14-RBM4–COAD

Open the COAD breakdown →