RASGRP4

Across TCGA patient cohorts, RASGRP4 mutation is significantly associated with the RNA expression of many other genes, with 3,148 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RASGRP4-associated genes across cancer lineages are PTP4A3, KIFBP, and KLRK1. Each is linked with RASGRP4 in more than 2 cancer types. Because this analysis shows association rather than direction, both RASGRP4-to-partner and partner-to-RASGRP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTP4A3 grouped by RASGRP4-low versus RASGRP4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RASGRP4→partner) and Y-score (partner→RASGRP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PTP4A3 →	-0.717	-3.989	<.001	<.001	3	3
UCEC	KIFBP →	+0.396	+1.809	.007	.001	3	3
UCEC	KLRK1 →	+0.143	+2.112	.009	<.001	3	3
UCEC	IL2RB →	+0.778	+2.389	<.001	<.001	3	3
UCEC	PUS3 →	+0.316	+2.389	.005	<.001	3	3
UCEC	ITK →	+0.421	+2.421	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,148 associations by consensus.

PTP4A3 by RASGRP4 expression — UCEC

Explore this box plot interactively →