RASGRP4

Across TCGA pan-cancer cohorts, RASGRP4 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of RASGRP4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RASGRP4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RASGRP4 is over-expressed in tumor, although a few such as LUAD and BLCA show the opposite, repressed pattern.

KIRC, LUAD, and BLCA are the cancer types where RASGRP4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RASGRP4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.263	<.001	12	view →
LUAD	Male	II,III,IV	−1.672	<.001	9	view →
BLCA	Male	All	−0.823	<.001	9	view →
COAD	Female	All	−0.657	<.001	9	view →
LUSC	Female	II,III,IV	−2.214	<.001	8	view →
KIRP	All	All	+0.603	<.001	7	view →
UCEC	All	All	−0.644	<.001	6	view →
THCA	Male	II,III,IV	+0.374	.001	6	view →
BRCA	All	II,III,IV	−0.362	<.001	6	view →
HNSC	Female	All	+0.452	.001	3	view →
LIHC	Male	All	−0.221	.038	2	view →
READ	Female	All	−0.774	.018	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

RASGRP4–KIRC

Open the KIRC breakdown →