RASGRP4

Across TCGA pan-cancer cohorts, RASGRP4 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated RASGRP4 data layer compared with 6 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RASGRP4 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated RASGRP4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, OV, and SCLC are the cancer types where RASGRP4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.702	0.540	<.001	96	view →
OV	OS	Quartile	III,IV	0.228	0.351	.002	56	view →
SCLC	OS	Tertile	IV	0.137	0.548	.004	50	view →
LUAD	OS	Quartile	All	0.516	0.298	.003	42	view →
LGG	DFS	Tertile	All	0.345	0.578	<.001	40	view →
LAML	DFS	Tertile	All	0.255	0.496	.002	36	view →
KIRC	DFS	Tertile	All	0.899	0.703	<.001	32	view →
STAD	DFS	Quartile	All	0.564	0.818	.009	25	view →
SKCM	OS	Quartile	II,III,IV	0.441	0.259	.002	21	view →
UCS	DFS	Quartile	II,III,IV	0.851	0.367	.004	20	view →
ESCA	DFS	Median	All	0.447	0.927	.003	15	view →
GBM	DFS	Median	All	0.159	0.245	.008	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

RASGRP4–HNSC (DFS)

Open the HNSC breakdown →