RASGRP4

Across TCGA cell cohorts, RASGRP4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,270 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RASGRP4-associated GO terms across cancer lineages are Nuclear export, Positive regulation of DNA repair, and Negative regulation of gene expression, epigenetic. Each is linked with RASGRP4 in more than 8 cancer types. Because this analysis shows association rather than direction, both RASGRP4-to-partner and partner-to-RASGRP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nuclear export grouped by RASGRP4-low versus RASGRP4-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RASGRP4→partner) and Y-score (partner→RASGRP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Nuclear export →	+0.067	+0.035	.007	.002	3	9
SOFT_TISSUE	Positive regulation of DNA repair →	+0.080	+0.213	<.001	.001	3	9
UPPER_AERODIGESTIVE_TRACT	Negative regulation of gene expression, epigenetic →	+0.072	+0.035	<.001	.002	3	9
UPPER_AERODIGESTIVE_TRACT	Epigenetic regulation of gene expression →	+0.069	+0.037	<.001	.001	3	9
UPPER_AERODIGESTIVE_TRACT	Viral translational termination-reinitiation →	+0.065	+0.035	.005	.003	3	9
UPPER_AERODIGESTIVE_TRACT	mRNA transcription by RNA polymerase II →	+0.090	+0.040	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,270 associations by consensus.

Nuclear export by RASGRP4 expression — UPPER_AERODIGESTIVE_TRACT

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