RASGRP4

Across TCGA cell cohorts, RASGRP4 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible RASGRP4-associated genes across cancer lineages are OR1N1, C9orf92, and SLC5A8. Each is linked with RASGRP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both RASGRP4-to-partner and partner-to-RASGRP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1N1 grouped by RASGRP4-low versus RASGRP4-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RASGRP4→partner) and Y-score (partner→RASGRP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR1N1 →	+0.039	+5.369	<.001	.004	3	1
SOFT_TISSUE	C9orf92 →	+0.194	+5.369	<.001	.004	3	1
SOFT_TISSUE	SLC5A8 →	+0.006	+4.930	<.001	.008	3	1
BLOOD_Leukemia	PROP1 →	+0.029	+4.874	<.001	.002	3	1
BREAST	OR7D4 →	+0.016	+5.781	<.001	.001	3	1
BREAST	OR14A2 →	+0.042	+5.169	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

OR1N1 by RASGRP4 expression — SOFT_TISSUE

Explore this box plot interactively →