RASGEF1C

Across TCGA patient cohorts, RASGEF1C mutation is significantly associated with the RNA expression of many other genes, with 2,071 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RASGEF1C-associated genes across cancer lineages are RNU6-258P, RNU6-1106P, and OR6R2P. Each is linked with RASGEF1C in more than 2 cancer types. Because this analysis shows association rather than direction, both RASGEF1C-to-partner and partner-to-RASGEF1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-258P grouped by RASGEF1C-low versus RASGEF1C-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RASGEF1C→partner) and Y-score (partner→RASGEF1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU6-258P →	+0.372	+4.712	<.001	.007	3	3
HNSC	RNU6-1106P →	+0.270	+6.038	<.001	<.001	3	3
BRCA	OR6R2P →	+0.118	+4.418	.007	.002	3	2
CESC	RN7SL813P →	+0.229	+5.103	<.001	.008	3	2
UCEC	RN7SL237P →	+0.231	+1.666	<.001	.006	3	2
UCEC	ODF3L2 →	+0.446	+3.056	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,071 associations by consensus.

RNU6-258P by RASGEF1C expression — LUAD

Explore this box plot interactively →