RAPGEF1

Across TCGA patient cohorts, RAPGEF1 mutation is significantly associated with the RNA expression of many other genes, with 4,237 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAPGEF1-associated genes across cancer lineages are RNU1-82P, RNU6-918P, and PINCR. Each is linked with RAPGEF1 in more than 3 cancer types. Because this analysis shows association rather than direction, both RAPGEF1-to-partner and partner-to-RAPGEF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-82P grouped by RAPGEF1-low versus RAPGEF1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAPGEF1→partner) and Y-score (partner→RAPGEF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU1-82P →	+0.161	+4.386	<.001	.008	3	4
PRAD	RNU6-918P →	+0.384	+5.166	<.001	.007	3	4
STAD	PINCR →	+0.283	+3.435	.008	.006	3	3
COAD	RPL17P50 →	+0.673	+3.739	<.001	<.001	3	3
UCEC	MYL12BP1 →	+0.373	+1.333	<.001	.002	3	3
UCEC	TOMM22 →	+0.248	+1.617	.009	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,237 associations by consensus.

RNU1-82P by RAPGEF1 expression — BRCA

Explore this box plot interactively →